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Agricultural Science and Food Processing, 2024, Volume 1, Issue 1: 21-28

Free Access | Research Article | 08 November 2024
1 College of Life Science, Northwest University, Xi’an 710069, China
2 Key Laboratory of Biotechnology of Shannxi Province, Xi’an 710069, China
3 Key Laboratory of Resource Biology and Biothchnology in Western China (Ministry of Education), Xi’an 710069, China
* Corresponding author: Bin Guo, email: [email protected]
Received: 27 September 2024, Accepted: 25 October 2024, Published: 08 November 2024  

Abstract
Huperzine A is an important drug for Alzheimer’s disease (AD) treatment, which is mainly extracted from the medicinal plant Huperzia serrata (Thunb.) Trev (Huperzia serrata Trev.). In present study, a new endophytic fungus (NWUHS002) producing Huperzine A was isolated from the Huperzia serrata Trev. with a yield of 5.20 µg/g. NWUHS002 was identified as Staphylotrichum by morphology and internal transcribed spacer (ITS) sequence. The discovery of NWUHS002 in Huperzia serrata Trev. can be used for the breeding of high-producing Huperzine A strains and the study of Huperzine A biosynthesis.

Graphical Abstract
A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.

Keywords
huperzine A
alzheimer’s disease
Huperzia serrata Trev.
endophyte

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Cite This Article
APA Style
Liu, R., Zhao, Y., Wang, H., Zhang, H., Yue, X., Guo, H., Luo, J., & Guo, B. (2024). A Novel Huperzine A-producing Endophytic Fungus NWUHS002 Isolated from Huperzia Serrata Trev.. Agricultural Science and Food Processing, 1(1), 21–28. https://doi.org/10.62762/ASFP.2024.857122

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