In the era of digital transformation, enterprise web applications have become indispensable tools for business operations, necessitating the efficient and reliable management of vast amounts of data. Data persistence is critical to ensure consistency, security, and scalability, especially in complex environments involving high concurrency and sensitive information. This paper reviews the key requirements for data persistence in enterprise-level web applications, such as reliability, security, scalability, and high availability, while addressing the challenges posed by modern business needs. Various persistence solutions, including relational databases, NoSQL databases, and distributed storage systems, are examined with respect to their performance in these critical areas. By providing a comprehensive analysis of these solutions, this paper aims to guide enterprises in selecting the most suitable data persistence approach to ensure long-term stability and regulatory compliance.